Neural correlates of cognitive intervention in persons at risk of developing Alzheimer's disease.

Cognitive training is an emergent approach that has begun to receive increased attention in recent years as a non-pharmacological, cost-effective intervention for Alzheimer's disease (AD). There has been increasing behavioral evidence regarding training-related improvement in cognitive performance in early stages of AD. Although these studies provide important insight about the efficacy of cognitive training, neuroimaging studies are crucial to pinpoint changes in brain structure and function associated with training and to examine their overlap with pathology in AD. In this study, we reviewed the existing neuroimaging studies on cognitive training in persons at risk of developing AD to provide an overview of the overlap between neural networks rehabilitated by the current training methods and those affected in AD. The data suggest a consistent training-related increase in brain activity in medial temporal, prefrontal, and posterior default mode networks, as well as increase in gray matter structure in frontoparietal and entorhinal regions. This pattern differs from the observed pattern in healthy older adults that shows a combination of increased and decreased activity in response to training. Detailed investigation of the data suggests that training in persons at risk of developing AD mainly improves compensatory mechanisms and partly restores the affected functions. While current neuroimaging studies are quite helpful in identifying the mechanisms underlying cognitive training, the data calls for future multi-modal neuroimaging studies with focus on multi-domain cognitive training, network level connectivity, and individual differences in response to training

Carbon disulphide promotes sprouting of potato minitubers

We investigated the effects of postharvest application of carbon disulphide (CS2) in various concentrations (0, 15, 25, 35, 45 and 55 ml m-3) and with different exposure duration (24, 48, 72 and 96 h) on breaking of dormancy and sprouting of potato (Solanum tuberosum L., cv. Marfona) minitubers of two ages (freshly harvested and one week after harvest) and two weight classes (1.5 and 12 g). In comparison with the control minitubers, CS2 treated minitubers showed significantly shorter dormancy and better sprouting. More rotting and weaker responses were observed in freshly harvested treated minitubers compared with minitubers treated one week after harvest. The number of sprouts per minituber and their length were significantly enhanced by treating minitubers with CS2 compared with the untreated control minitubers, but there were strong interactions with minituber weight. Results showed that duration of CS2 treatment was more important than concentration and longer duration of CS2 treatment exhibited a stronger action on breaking dormancy and sprouting of potato minitubers than shorter treatments. But, when longer duration was accompanied with higher concentration, treatment with CS2 led to formation of needle sprouts, which are undesirable as they do not produce vigorous stem

Knowledgezoom for java: A concept-based exam study tool with a zoomable open student model

This paper presents our attempt to develop a personalized exam preparation tool for Java/OOP classes based on a fine-grained concept model of Java knowledge. Our goal was to explore two most popular student model-based approaches: open student modeling and problem sequencing. The result of our work is a Java exam preparation tool, Knowledge Zoom. The tool combines an open concept-level student model component, Knowledge Explorer and a concept-based sequencing component, Knowledge Maximizer into a single interface. This paper presents both components of Knowledge Zoom, reports results of its evaluation, and discusses lessons learned. © 2013 IEEE

A Mobile Geo-Communication Dataset for Physiology-Aware DASH in Rural Ambulance Transport

Use of telecommunication technologies for remote, continuous monitoring of patients can enhance effectiveness of emergency ambulance care during transport from rural areas to a regional center hospital. However, the communication along the various routes in rural areas may have wide bandwidth ranges from 2G to 4G; some regions may have only lower satellite bandwidth available. Bandwidth fluctuation together with real-time communication of various clinical multimedia pose a major challenge during rural patient ambulance transport.; AB@The availability of a pre-transport route-dependent communication bandwidth database is an important resource in remote monitoring and clinical multimedia transmission in rural ambulance transport. Here, we present a geo-communication dataset from extensive profiling of 4 major US mobile carriers in Illinois, from the rural location of Hoopeston to the central referral hospital center at Urbana. In collaboration with Carle Foundation Hospital, we developed a profiler, and collected various geographical and communication traces for realistic emergency rural ambulance transport scenarios. Our dataset is to support our ongoing work of proposing "physiology-aware DASH", which is particularly useful for adaptive remote monitoring of critically ill patients in emergency rural ambulance transport. It provides insights on ensuring higher Quality of Service (QoS) for most critical clinical multimedia in response to changes in patients' physiological states and bandwidth conditions. Our dataset is available online for research community.Comment: Proceedings of the 8th ACM on Multimedia Systems Conference (MMSys'17), Pages 158-163, Taipei, Taiwan, June 20 - 23, 201